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  • Title: Functional supersensitivity of CNS alpha 1-adrenoceptors following chronic antidepressant treatment.
    Author: Menkes DB, Kehne JH, Gallager DW, Aghajanian GK, Davis M.
    Journal: Life Sci; 1983 Jul 11; 33(2):181-8. PubMed ID: 6306376.
    Abstract:
    Chronic but not acute administration (21 days) of desipramine (10 mg/kg), amitriptyline (10 mg/kg) or iprindole (5 mg/kg) enhanced the stimulatory effect of the alpha 1-adrenergic agonist phenylephrine on the acoustic startle reflex when phenylephrine was infused into the subarachnoid space of the spinal cord. Comparable supersensitivity to phenylephrine also occurred 1 week after selective depletion of norepinephrine in the spinal cord via intrathecal administration of 6-hydroxydopamine. Behavioral supersensitivity to phenylephrine was associated with an increase in the number of 3H-prazosin binding sites following denervation but not following chronic antidepressant treatments. The results indicate that chronic antidepressant treatments may enhance functional alpha 1-adrenergic transmission through mechanisms different than those following denervation.
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