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  • Title: Relationship between relaxation and cyclic GMP formation caused by nicorandil in canine mesenteric artery.
    Author: Endoh M, Taira N.
    Journal: Naunyn Schmiedebergs Arch Pharmacol; 1983 May; 322(4):319-21. PubMed ID: 6306488.
    Abstract:
    In the isolated canine mesenteric artery relaxation caused by nicorandil [N-(2-hydroxyethyl)nicotinamide nitrate ester; SG-75] in the presence of noradrenaline was accompanied by a concomitant elevation of cGMP level, whilst the cAMP level was not changed by the drug. The relaxation and cGMP level after the administration of nicorandil showed a good correlation. In this respect nicorandil is very similar to nitrogen oxide-containing vasodilators.
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