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  • Title: Endotoxin-induced formation of specific beta-endorphin binding sites in human serum.
    Author: Schweigerer L.
    Journal: Biochem Biophys Res Commun; 1983 Jun 29; 113(3):839-44. PubMed ID: 6307304.
    Abstract:
    Specific binding of human beta-endorphin is demonstrated to sites that are present in endotoxin-treated, but not in native, human serum. Binding is saturable and reversible and is mediated by a nonopioid segment of beta H-endorphin to sites that are located on the terminal SC5b-9 complement complex. Since endotoxemia causes both the secretion of beta-endorphin into blood (1) and the formation of specific beta-endorphin binding sites therein, both effects might be elements of a common physiological process.
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