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  • Title: [Opiate receptor(s) of the frog brain: soluble-phase separation of the macromolecular complexes of an agonist and an antagonist].
    Author: Puget A, Meunier JC.
    Journal: C R Seances Acad Sci III; 1983; 296(10):475-8. PubMed ID: 6307492.
    Abstract:
    Frog brain membranes, pre-labelled with the opiate agonist 3H-etorphine or with the opiate antagonist 3H-diprenorphine, are solubilized with digitonin. The soluble digitonin extract is centrifuged in linear sucrose gradients. Under these conditions, we separate an agonist macromolecular complex and an antagonist macromolecular complex, the former sedimenting faster than does the latter. This difference in apparent molecular size might reflect an agonist-induced coupling between opiate receptor and other membrane components.
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