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  • Title: Effect of ceftizoxime, a new cephalosporin antibiotic, on binding of bilirubin to human serum albumin.
    Author: Sakamoto H, Murakawa T, Hirose T, Nishida M.
    Journal: Chemotherapy; 1983; 29(4):244-8. PubMed ID: 6307603.
    Abstract:
    An investigation and comparison of the competitive effect of ceftizoxime, a new cephalosporin, and other beta-lactam antibiotics on in vitro binding of bilirubin to human serum albumin showed that at a normal range of serum albumin (3.48 g/dl) and bilirubin (0.94 mg/dl) in healthy infants, free bilirubin did not increase in the presence of any of the test antibiotics at concentrations up to 640 micrograms/ml. When the albumin concentration was decreased to one-fifth of the normal human range, only ceftizoxime caused no bilirubin displacement.
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