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  • Title: Brain receptor binding of analogues of gamma-aminobutyric acid (GABA).
    Author: Borea PA, Bonora A, Baraldi PG, Simoni D.
    Journal: Farmaco Sci; 1983 Jun; 38(6):411-7. PubMed ID: 6307745.
    Abstract:
    This paper reports the synthesis of some 4-(beta-hydroxyalkyl)-gamma-aminobutyric acid analogues (I a-h). The compounds were biologically tested as inhibitors of 3H-GABA binding to rat cortex synaptosomal membranes. The most potent compounds were (I c,d) which exhibited a linear alkyl chain at C4.
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