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  • Title: [New recommendations for the completion of rhesus-immunization prophylaxis with anti-D].
    Author: Maas DH, Schneider J.
    Journal: Immun Infekt; 1982 Nov; 10(6):244-9. PubMed ID: 6307863.
    Abstract:
    Despite the successful prevention of the Rhesus-isoimmunization in Rhesus-negative mothers after delivery of a Rhesus-positive child by immunoglobulin anti-D injected post partum, some women still get sensitized against the Rhesus-antigen by transplacental haemorrhages occurring during pregnancy or in miscarriages, abortions or ectopic pregnancies. Besides that, failures of the Rhesus-prophylaxis may be caused by large volumes of fetal blood transferred to the maternal circulation - especially in complicated deliveries. We therefore recommend to give immunoglobulin anti-D during pregnancy whenever there is a reported risk of significant transplacental haemorrhages. Further we urge to count the fetal cells in the maternal blood after each delivery to adjust the anti-D-dosage to the volume of the transplacental haemorrhage.
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