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  • Title: An ELISA technique to detect IgG antibody to the early herpes simplex virus type 2 (HSV-2) antigen AG-4 in HSV-2 patients.
    Author: Evans L, Arsenakis M, Sheppard M, May JT.
    Journal: J Virol Methods; 1983 May; 6(5):245-54. PubMed ID: 6308025.
    Abstract:
    An ELISA system, based on urease activity was used for the detection and titration of IgG to the immediate early AG-4 antigen in sera from HSV-2 patients. It detected low levels of IgG to the AG-4 antigen in 32% of patients' sera known to contain complement fixing antibody to the antigen. Furthermore, the sensitivity of the ELISA system was 2- to 10-fold higher than the complement-fixation system depending on when the sera was taken from the HSV-2 patients. The system also allowed the easy detection and quantitation of AG-4 antigen production when various HSV-1 X HSV-2 intertypic recombinant viruses were used to infect BHK-21 cells.
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