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  • Title: Detection and persistence of specific IgA antibodies in serum of patients with hepatitis A by capture radioimmunoassay.
    Author: Sikuler E, Keynan A, Hanuka N, Friedman MG, Sarov I.
    Journal: J Med Virol; 1983; 11(4):287-94. PubMed ID: 6308139.
    Abstract:
    The serum immunoglobulin A (IgA) response to hepatitis A virus (HAV) was investigated with a sensitive capture radioimmunoassay. In serial serum samples drawn from 15 patients with viral hepatitis A, IgA anti-HAV antibodies reached their highest titer between 1-2 weeks after onset and peak titers ranged from 10,000-20,000. Serum samples were available from six patients 30-32 months after onset of illness. These samples were all positive for IgA anti-HAV and some had titers similar to peak titers during illness. However, the height of the titration curves, expressed as the binding ratio (BR) at a dilution of 1/1000, was in all cases significantly lower at 30-32 months than during acute illness and early convalescence. The significance of the persistence of the IgA anti-HAV and possible reasons for the change in the BR are discussed.
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