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  • Title: Synthesis of three potential inhibitors of leukotriene biosynthesis.
    Author: Pfister JR, Murthy DV.
    Journal: J Med Chem; 1983 Aug; 26(8):1099-103. PubMed ID: 6308255.
    Abstract:
    The syntheses of 7,7-dimethyl- (1), 10,10-dimethyl- (2), and 5,6-benzoarachidonic acid (3), potential substrate analogue inhibitors of leukotriene biosynthesis, are described. Two of these compounds (1 and 2) apparently stimulated, while 3 inhibited, the activity of lipoxygenase from intact human polymorphonuclear leukocytes in vitro when stimulated with Ca2+ and calcium ionophore A23187 in the presence of BSA and arachidonic acid.
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