These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Identification and the origin of oncogenes, with special reference to sarcoma virus Y73].
    Author: Yoshida M.
    Journal: Gan To Kagaku Ryoho; 1983 Feb; 10(2 Pt 2):504-11. PubMed ID: 6309089.
    Abstract:
    A new sarcomagenic transforming gene, yes, was identified in an avian sarcoma virus Y73. The gene product is a gag-fused polyprotein p90yes and have protein kinase activity phosphorylating tyrosine residues in proteins. Vertebrates from fish to human were shown to contain DNA sequence (c-yes) homologous with viral yes. Total nucleotide sequence of Y73 genome was determined and the predicted amino acid sequence of p90yes was found to be highly homologous with p60src, a gene product of src in Rous sarcoma virus. These findings suggest that transforming gene yes and src are diverged from a common prototype onc gene at very early stage of vertebrate development or before that and conserved during the development since it plays an essential role.
    [Abstract] [Full Text] [Related] [New Search]