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  • Title: Acquired hypogammaglobulinemia following infectious mononucleosis.
    Author: Greally JF, Lawlor E, Lyons J, Rickinson A, Sakamoto K, Purtilo D.
    Journal: J Clin Immunol; 1983 Jul; 3(3):207-11. PubMed ID: 6309893.
    Abstract:
    The case of a 17-year-old male who developed hypogammaglobulinemia following infectious mononucleosis is presented. The family history revealed that a male sibling had died some years earlier with encephalitis also following infectious mononucleosis. Laboratory investigations revealed adequate numbers of T and B cells and normal proportions of helper and suppressor T lymphocytes but poor in vitro responses to mitogens and an absence of hypersensitivity to skin test antigens. Serial serological examinations for Epstein-Barr virus antibodies indicated a primary immune response to this virus in a hypogammaglobulinemic individual. The patient probably represents a case of the X-linked lymphoproliferative syndrome. The unique feature of the present case is the demonstration of Epstein-Barr virus-specific T-cell memory. The significance of this finding and the variable expression of this syndrome in two members of the same family are discussed.
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