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  • Title: Prolonged foot-shock induced analgesia: glucocorticoids and non-pituitary opioids are involved.
    Author: Lim AT, Oei TP, Funder JW.
    Journal: Neuroendocrinology; 1983 Jul; 37(1):48-51. PubMed ID: 6310428.
    Abstract:
    In rats, the analgesic response induced by prolonged intermittent foot-shock is abolished by naloxone or adrenalectomy, and is restored in adrenalectomized animals by the administration of dexamethasone or corticosterone, but not deoxycorticosterone. Levels of immunoreactive beta-endorphin in the anterior pituitary are significantly elevated by adrenalectomy alone, and further by dexamethasone and corticosterone; in contrast, immunoreactive beta-endorphin levels in the neuro-intermediate lobe are raised by deoxycorticosterone. These findings suggest that analgesic responses produced by prolonged intermittent foot-shock involve both the pituitary-adrenal axis and endogenous, non-pituitary opioids.
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