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  • Title: Enkephalin blocks primary afferent depolarization of A delta tooth pulp afferents evoked by stimulation in nucleus raphe magnus in the decerebrate cat.
    Author: Lovick TA.
    Journal: Neurosci Lett; 1983 Jun 30; 37(3):273-8. PubMed ID: 6310455.
    Abstract:
    Electrical stimulation in nucleus raphe magnus (NRM) in decerebrate cats produced an increase in the excitability of tooth pulp afferent terminals in trigeminal nucleus oralis and caudalis. Iontophoretic application of Met5-enkephalin near the terminal region did not affect resting terminal excitability but reduced the effectiveness of NRM stimulation to increase terminal excitability. This effect of enkephalin was blocked by naloxone. It is concluded that enkephalin may have reduced the primary afferent depolarization (PAD) evoked from NRM by inhibiting GABA-containing neurones which mediate PAD in the spinal trigeminal nucleus.
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