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  • Title: Ouabain-like activity in human cerebrospinal fluid.
    Author: Halperín J, Schaeffer R, Galvez L, Malavé S.
    Journal: Proc Natl Acad Sci U S A; 1983 Oct; 80(19):6101-4. PubMed ID: 6310614.
    Abstract:
    Human cerebrospinal fluid has been found to mimic the effect of ouabain on net Na+ efflux and 86Rb+ influx across erythrocyte membranes and on the in vitro activity of a purified Na+/K+-ATPase (ATP phosphohydrolase, EC 3.6.1.3) derived from canine kidney. These results indicate the possible existence in human cerebrospinal fluid of an endogenous factor with ouabain-like activity, which might be linked to sodium metabolism.
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