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Title: Is cytosolic ionized calcium regulating neutrophil activation? Author: Pozzan T, Lew DP, Wollheim CB, Tsien RY. Journal: Science; 1983 Sep 30; 221(4618):1413-5. PubMed ID: 6310757. Abstract: The concentration of cytosolic ionized calcium, [Ca2+]i, was measured in intact neutrophils by use of a fluorescent indicator trapped in the icytoplasm. A given rise of [Ca2+]i elicited by the chemotactic peptide formylmethionylleucylphenylalanine (FMLP) was associated with a much greater degree of superoxide generation and myeloperoxidase secretion than was the same or larger [Ca2+]i produced by a specific calcium ionophore, ionomycin, which bypasses cell surface receptors. Thus, FMLP appears to generate some important excitatory signal in addition to a rise in [Ca2+]i and exocytosis and superoxide generation in neutrophils may not be simply dependent on [Ca2+]i as is widely supposed.[Abstract] [Full Text] [Related] [New Search]