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  • Title: [Intratumor chemotherapy of patients with cancer of the ovaries].
    Author: Vinokurov VL, Mitrokhina MV.
    Journal: Vopr Onkol; 1983; 29(8):58-61. PubMed ID: 6310891.
    Abstract:
    The paper presents the results of intratumoral chemotherapy of 32 cases of single metastases of stage III-IV ovarian cancer into the Douglas pouch. The metastases were detected at different stages after primary treatment. Thiotepa, cyclophosphamide, sarcolysin and methotrexate were administered in 81.2, 9.4, 6.2 and 3.1% of cases, respectively. A clinically-significant effect was recorded in 14 out of 32 cases (43.7%); tumor process was arrested in 15 cases (46.9%); treatment failed in 3 cases (9.4%). Toxic side-effects were less frequent and pronounced than in patients given standard systemic monochemotherapy.
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