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  • Title: [Effect of izadrin, inderal and netalid on the periodic activity of the rabbit myometrium].
    Author: Koroza GS, Kudrin AN.
    Journal: Farmakol Toksikol; 1976; 39(2):155-9. PubMed ID: 6311.
    Abstract:
    The contractility of an isolated rabbit uterus was studied. It was found that when used in low concentrations (1.10(-9)-1.10(-7) g/ml) isoprenaline, while stimulating the beta-adrenoreceptors of the uterus, inhibits its contractions, whereas in high concentrations (1.10(6)-1.10(-5) g/ml) it is capable of intensifying uterine contractions owing to stimulation of the uterine alpha-adrenoreceptors. Dihydroergotoxin (1.10(-6) g/ml), a blocking agent of alpha-adrenoreceptors, averts and eliminates the stimulating effect of isoprenaline on the uterus. Propranolol and netalide, blocking agents of the beta-adrenoreceptors, abolish the already developed depressing action of isoprenaline on the contractile activity of the uterus, but fail to prevent this effect with their preliminary application.
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