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  • Title: Spontaneous endocrine cure of gigantism due to pituitary apoplexy.
    Author: Arisaka O, Hall R, Hughes IA.
    Journal: Br Med J (Clin Res Ed); 1983 Oct 08; 287(6398):1007-8. PubMed ID: 6311318.
    Abstract:
    An 11 year old, tall boy presented with symptoms typical of pituitary apoplexy. A large necrotic and haemorrhagic tumour was removed, which was shown to be an adenoma secreting growth hormone and prolactin. Subsequent treatment comprised cranial irradiation and hormone replacement. Eighteen months after operation growth was static and plasma growth hormone and prolactin concentrations were undetectable. Treatment of pituitary apoplexy should comprise excision of the tumour and postoperative irradiation; such treatment after early recognition of the condition offers the best chance of preserving normal pituitary function in children with gigantism.
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