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  • Title: Comparison of the alpha-adrenoceptor profiles of clonidine and two oxygenated arylamino imidazolines.
    Author: Chapleo CB, Doxey JC, Frank LW, Myers PL, Roach AG, Smith CF, Virdee NK.
    Journal: Eur J Pharmacol; 1983 Jul 15; 91(1):123-8. PubMed ID: 6311568.
    Abstract:
    The profiles of 2-(3,4-dimethoxyphenylamino)-imidazoline HCl (RX 77171) and 2-[6-(1,4-benzodioxanylamino)]imidazoline maleate (RX 801074) were compared with that of clonidine in isolated tissues and pithed rats. RX 77171 consistently displayed prejunctional alpha 2-adrenoceptor antagonist and postjunctional agonist properties. In contrast, RX 801074 had a complex profile which showed considerable variability between tissues. This variability is highlighted by comparing its effects at the prejunctional alpha 2-adrenoceptors of the isolated vas deferens and guinea-pig ileum; in the former RX 801074 was an agonist whereas only antagonist properties were apparent in the ileum.
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