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  • Title: Comparative measurement of the lactogenic activity of ovine placental lactogen in rabbit and ewe mammary gland.
    Author: Servely JL, Emane MN, Houdebine LM, Djiane J, Delouis C, Kelly PA.
    Journal: Gen Comp Endocrinol; 1983 Aug; 51(2):255-62. PubMed ID: 6311665.
    Abstract:
    Ovine placental lactogen is known to bind to prolactin receptors and to initiate milk synthesis in the rabbit mammary gland. However, this hormone exhibited a very low capacity of competing with 125I-labeled human growth hormone for the binding to membranes extracted from ewe mammary gland. Ovine placental lactogen was very efficient in provoking the accumulation of beta-casein mRNA in rabbit mammary explants but was much less active on ewe mammary explants. These data indicate that the placental hormone is not a potent lactogen in the homologous species and that its role in the control of mammary gland development and activity may have been previously overestimated.
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