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  • Title: Randomized study of ceftazidime versus gentamicin plus cefotaxime for infections in severe granulocytopenic patients.
    Author: de Pauw BE, Kauw F, Muytjens H, Williams KJ, Bothof T.
    Journal: J Antimicrob Chemother; 1983 Jul; 12 Suppl A():93-9. PubMed ID: 6311790.
    Abstract:
    A randomized study of gentamicin plus cefotaxime versus ceftazidime alone was performed in 87 patients, with a neutrophil count of less than 1000/mm3 at the start of the treatment. The overall cure rate for the ceftazidime group was 71% and for the gentamicin plus cefotaxime 47%. This difference was shown to be statistically significant at a level of P less than 0.05. The cure rates for the microbiologically proven infections were 90 and 63% respectively. Serious adverse effects, causing preliminary withdrawal of therapy, have not been observed.
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