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  • Title: [3H]muscimol binding site on purified benzodiazepine receptor.
    Author: Martini C, Rigacci T, Lucacchini A.
    Journal: J Neurochem; 1983 Oct; 41(4):1183-5. PubMed ID: 6311980.
    Abstract:
    The presence of a [3H]muscimol binding site on the purified benzodiazepine receptor was demonstrated. The purified protein was apparently homogeneous as shown by sodium dodecyl sulfate polyacrylamide gel electrophoresis (stained with silver), with a molecular weight of 60,000 +/- 3000. The benzodiazepine binding sites were characterized as being of the central type and the [3H]flunitrazepam binding was enhanced by GABA. This activation was antagonized by bicuculline. [3H]Muscimol specifically binds to the benzodiazepine receptor. The Scatchard plot indicates a Kd of 23 nM and the ratio [3H]flunitrazepam/[3H]muscimol is approximately unity.
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