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  • Title: Coxsackie B virus antibodies in myocardial infarction.
    Author: Nikoskelainen J, Kalliomäki JL, Lapinleimu K, Stenvik M, Halonen PE.
    Journal: Acta Med Scand; 1983; 214(1):29-32. PubMed ID: 6312770.
    Abstract:
    Evidence for the association between Coxsackie B virus infections and myocardial infarction was studied in a prospective follow-up examination. Using the micro neutralization test, 9 (15%) of 59 patients with acute myocardial infarction and 1 (2.6%) of 38 control patients showed a fourfold, or higher, antibody increase in paired serum samples against Coxsackie B1-5 viruses. This difference is significant (p less than or equal to 0.05). None of the patients or controls revealed symptoms of a viral infection during the blood sampling. Virus isolation from throat and feces was negative in all patients and controls. This finding agrees with some previous studies suggesting that the Coxsackie B group may in some cases have a causal role in myocardial infarction, or may act as a triggering factor.
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