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  • Title: [Derivatives of 3-hydrazinopyridazine. II. Synthesis and antihypertensive activity of new 3-hydrazino-6-monoalkylaminopyridazines].
    Author: Parravicini F, Scarpitta G, Dorigotti L, Pifferi G.
    Journal: Farmaco Sci; 1978 Feb; 33(2):99-105. PubMed ID: 631323.
    Abstract:
    The synthesis of some 3-hydrazino-6-monoalkylaminopyridazines (VIII) by reaction of 3,6-dichloropyridazine with various N-monoalkylbenzylamines, followed by reaction with hydrazine and final debenzylation in an acidic medium, is described. The new compounds were evaluated as antihypertensive agents and exhibited the same or higher activity than hydralazine, but lower activity than propildazine (ISF 2123).
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