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  • Title: Inhibition of guinea-pig renal [Na + K]-ATPase by normotensive human plasma: effects of a high sodium diet.
    Author: Wellard RM, Myers JB, Danks JA, Morgan TO, Adam WR.
    Journal: Clin Exp Pharmacol Physiol; 1983; 10(3):261-4. PubMed ID: 6313263.
    Abstract:
    The effect of plasma taken from normotensive humans, while on a low and high sodium diet, on [Na + K]-ATPase and 3H-ouabain binding was measured in tubules from guinea-pig kidneys. Plasma from the high sodium, compared to the low sodium, diet period: (a) inhibited [Na + K]-ATPase activity; (b) decreased 3H-ouabain affinity for binding sites; (c) increased the number of available 3H-ouabain binding sites; (d) decreased [Na + K]-ATPase turnover (activity/3H-ouabain binding sites). The inhibition of [Na + K]-ATPase suggests an increase in a (possible) natriuretic factor. The decreased affinity of 3H-ouabain binding suggests an endogenous ouabainoid, which may be the natriuretic factor.
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