These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Expression of eight unrelated Muc+ plasmids in eleven DNA repair-deficient E. coli strains.
    Author: Upton C, Pinney RJ.
    Journal: Mutat Res; 1983 Oct; 112(5):261-73. PubMed ID: 6314133.
    Abstract:
    23 plasmids from different incompatibility groups were tested for their ability to increase post-UV survival and UV-induced reversion to Arg+ in Escherichia coli strain AB1157 argE3 8 plasmids increased mutagenesis, of which 7 increased UV resistance. The exception, plasmid R391, sensitized AB1157 to UV. All 8 plasmids were absolutely dependent upon host recA+ and lexA+ genotypes for expression of these functions, but were independent of uvrA+, uvrB+, umuC+, recF+, polA+, uvrD+ or recL+. E. coli KMBL91 uvrE was sensitized to UV by R391, but protected by only 3 plasmids. All 8 plasmids restored mutation frequency in the non-mutable TK501 uvrB umuC strain to levels found in the JC3890 uvrB umuC+ parent strain. R391 sensitized TK501 to UV, but all other plasmids increased survival in the strain by over 1000-fold to levels found in the JC3890 uvrB umuC+ R+ strains. Plasmid R391 reduced the UV-protecting effect of R46 when both were present in strain TK501. Mutation frequencies were higher in TK501 (R46) than in TK501 (R391); in TK501 (R46/R391) they were slightly lower than in TK501 (R46).
    [Abstract] [Full Text] [Related] [New Search]