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  • Title: [Isolation and characteristics of a mutant herpes simplex virus type 1 resistant to phosphonoacetic acid].
    Author: Gibadulin RA, Denisova TS, Zavgorodniĭ SG, Florent'ev VL, Zhdanov VM.
    Journal: Vopr Virusol; 1983; 28(4):59-63. PubMed ID: 6314671.
    Abstract:
    By successive passages and triple cloning of herpes simplex virus type 1 (HSV-1) in Vero cell culture in the presence of increasing concentrations of phosphonoacetic acid (PAA) a mutant of HSV-1 resistant to PAA (PAAr) was derived and characterized. The resistance to the inhibitor was transmitted from PAAr-mutant to a sensitive strain (L2) by recombination performed by the marker rescue method using DNA fragmented by Hpa-1 restrictase. The resulting recombinant (R-551) was resistant to the inhibitor and had an altered primary structure of DNA.
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