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  • Title: Binding of [3H]flunitrazepam and [3H]Ro5-4864 to crude homogenates of amygdala-kindled rat brain: two months post-seizure.
    Author: Burnham WM, Niznik HB, Okazaki MM, Kish SJ.
    Journal: Brain Res; 1983 Nov 21; 279(1-2):359-62. PubMed ID: 6315180.
    Abstract:
    The binding of [3H]flunitrazepam and [3H]Ro5-4864 to crude homogenates of amygdala-kindled and 'yoked' control rat brains was evaluated in subjects sacrificed 60 days after the sixth generalized convulsion. Decreases in the Bmax for [3H]flunitrazepam binding to 'central-type' benzodiazepine receptors were observed in the hypothalamus and ipsilateral cortex of kindled animals. The binding of [3H]Ro5-4864 to 'peripheral-type' benzodiazepine receptors was unchanged.
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