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  • Title: A comparison of the pharmacokinetics and tissue penetration of ceftriaxone, moxalactam and cefotaxime.
    Author: Wise R, Andrews JM.
    Journal: Eur J Clin Microbiol; 1983 Oct; 2(5):505-8. PubMed ID: 6315427.
    Abstract:
    One gram each of moxalactam and cefotaxime and 0.5 g of ceftriaxone was administered intravenously to six volunteers. The pharmacokinetics and tissue penetration (as measured by a blister fluid model) were studied. The initial (i.e. 15 min) concentrations of the agents were 89.7 mg/l, 101 mg/l and 55 mg/l for ceftriaxone, moxalactam and cefotaxime respectively. The serum half-lives differed considerably, being 8.8, 2.8 and 1.2 h respectively. All agents penetrated the blister fluid rapidly the maximum penetration being found with ceftriaxone, namely 32.7 mg/l.
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