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  • Title: Peptide E and other proenkephalin-derived peptides are potent kappa opiate receptor agonists.
    Author: Quirion R, Weiss AS.
    Journal: Peptides; 1983; 4(4):445-9. PubMed ID: 6316294.
    Abstract:
    Various proenkephalin-derived peptides such as peptide E and the bovine adrenal medulla peptides BAM-12P and BAM-22P are potent competitors on mu and kappa binding sites in guinea pig brain sections. Moreover, they are all potent agonists in the rabbit vas deferens, a specific kappa opiate receptor bioassay. As described before, dynorphin and some of its fragments are also potent kappa agonists. Our results suggest that not only prodynorphin-derived peptides could act as endogenous kappa ligands but also some proenkephalin-derived peptides such as peptide E.
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