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Title: [Effect of cholecystokinin octapeptide on brain monoamine levels during feeding and drinking motivational excitation]. Author: Timofeeva LV, Timofeev NA, Kadar T, Varsegi M, Zhuravlev BV, Telegdi G. Journal: Zh Vyssh Nerv Deiat Im I P Pavlova; 1983; 33(5):936-40. PubMed ID: 6316687. Abstract: The paper presents studies of the influence of octapeptide cholecystokinin (ChCK-8) on the level of dofamine, noradrenaline and serotonine in the hypothalamus, septum, amygdala, striatum and mesencephalon of the rats brain during 24-, 48- and 96-hour alimentary and water deprivation. A change of catecholamines content under the influence of ChCK-8 was observed for the most part in conditions of thirst and only in the hypothalamus. ChCK-8 action in conditions of water deprivation was selective and directed mainly to the restoration of the changes in transmitter's level. ChCK-8 did not have a significant influence on the level of the brain monoamines during hunger. It may be assumed, that "satiation" hormone ChCK-8 is to a great extent connected with the mechanisms of reinforcement, and its "satiating" effect would appear at catecholamines' level in the process of satisfying of corresponding need.[Abstract] [Full Text] [Related] [New Search]