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  • Title: Involvement of polyADP-ribose polymerase in the initiation of phytohemagglutinin induced human lymphocyte proliferation.
    Author: Ittel ME, Jongstra-Bilen J, Rochette-Egly C, Mandel P.
    Journal: Biochem Biophys Res Commun; 1983 Oct 31; 116(2):428-34. PubMed ID: 6316953.
    Abstract:
    Nicotinamide (10 mM) or 3-aminobenzamide (5 mM) added at the onset of phytohemagglutinin (PHA) treated human lymphocyte cultures provoke a marked inhibition of the PHA induced DNA synthesis and cell proliferation as well as of poly(ADPR) polymerase activity. When the inhibitors of poly(ADPR) polymerase are added at a later stage of culture (48 h) no inhibition of the stimulation of DNA synthesis and cell proliferation by PHA in human lymphocyte cultures is observed. The intervention of ADP ribosylation at the initiation of DNA synthesis is suggested.
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