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  • Title: Dissociation of presynaptic alpha 2-adrenoceptors following prazosin administration: presynaptic effect of prazosin.
    Author: Vizi ES, Ludvig N, Rónai AZ, Folly G.
    Journal: Eur J Pharmacol; 1983 Nov 25; 95(3-4):287-90. PubMed ID: 6317415.
    Abstract:
    Evidence has been obtained that prazosin possesses a presynaptic alpha 2-adrenoceptor blocking action in the rat was deferens preparation stimulated at 1 Hz. In the presence of prazosin yohimbine failed to affect the presynaptic alpha 2-adrenoceptor stimulatory effect of 1-noradrenaline while the effect of xylazine was almost completely abolished. It is therefore suggested that there are two kinetically different prejunctional alpha 2-adrenoceptor sites.
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