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  • Title: The development of vasopressin antagonists.
    Author: Sawyer WH, Manning M.
    Journal: Fed Proc; 1984 Jan; 43(1):87-90. PubMed ID: 6317468.
    Abstract:
    Antagonists of the physiological actions of vasopressin can be useful probes for detecting the influences of endogenous vasopressin on cardiovascular regulation. Antagonists that block vascular receptors of the V1 type have been widely used for this purpose. Recently effective antagonists of renal antidiuretic receptors of the V2 type have become available, and we have made progress toward improving their specificity for V2 receptors. Vasopressin antagonists of both types of responses could become useful in the diagnosis and treatment of pathophysiological states in which elevated levels of circulating vasopressin may disturb cardiovascular and renal functions.
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