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  • Title: Angiotensin-converting enzyme, bradykinin, angiotensin, and cerebral vessel reactivity.
    Author: Whalley ET, Wahl M, Sampaio CA.
    Journal: Hypertension; 1983; 5(6 Pt 3):V34-7. PubMed ID: 6317557.
    Abstract:
    Bradykinin (BK) produced concentration-related relaxations of cat middle cerebral arteries and was ineffective in cat basilar arteries. On rabbit basilar arteries, BK initially produced concentration-related relaxations; however, when repeated at 2-hour intervals, BK eventually produced pure contractile responses. After preincubation of the tissues with cycloheximide, BK produced reproducible relaxation responses. The angiotensin-converting enzyme inhibitors, SQ 14,225, BPP5a, and BPP9a, had no effect on the concentration-effect curves of BK, AII, or 5-HT with any of the preparations, but responses to AI were inhibited. These results suggest that, in these tissues, angiotensin-converting enzyme is important for conversion of AI to AII, but apparently not for the degradation of BK.
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