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  • Title: Gene product of v-fgr onc: hybrid protein containing a portion of actin and a tyrosine-specific protein kinase.
    Author: Naharro G, Robbins KC, Reddy EP.
    Journal: Science; 1984 Jan 06; 223(4631):63-6. PubMed ID: 6318314.
    Abstract:
    The nucleotide sequence of the region of Gardner-Rasheed feline sarcoma virus (GR-FeSV) encoding its primary translation product, p70gag-fgr, has been determined. From the nucleotide sequence, the amino acid sequence of this transforming protein was deduced. Computer analysis indicates that a portion of P70gag-fgr has extensive amino acid sequence homology with actin, a eukaryotic cytoskeletal protein. A second region of P70gag-fgr is closely related to the tyrosine-specific kinase gene family. Thus, the v-fgr oncogene appears to have arisen as a result of recombinational events involving two distinct cellular genes, one coding for a structural protein and the other for a protein kinase.
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