These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Pharmacokinetic profile of a slow-release ketoprofen preparation].
    Author: Flouvat B, Stheneur A, Massias P.
    Journal: Sem Hop; 1983 Dec 12; 59(46):3187-90. PubMed ID: 6318337.
    Abstract:
    Kinetics of ketoprofen release in man from a sustained-release preparation (150 mg) and from capsules (3 X 50 mg) were studied comparatively in 10 healthy adults. Bioavailability of the slow-release preparation is similar to that of capsules : surfaces under the serum concentration curves and urinary elimination were found to be identical. In the sustained-release preparation the immediately available layer (75 mg) ensures achievement of maximal serum concentrations amounting to 59% of those obtained with capsules, after the same time interval. The slow-release layer (75 mg) produces higher serum concentrations from the third hour on, justifying administration of the formulation in two daily doses.
    [Abstract] [Full Text] [Related] [New Search]