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  • Title: [Modulation of the expression of transferrin receptors by iron, hemin and protoporphyrin IX].
    Author: Louache F, Testa U, Thomopoulos P, Titeux M, Rochant H.
    Journal: C R Seances Acad Sci III; 1983; 297(6):291-4. PubMed ID: 6318930.
    Abstract:
    The expression of transferrin receptors in human leukemic cell lines was investigated. Our results have clearly shown that heme, iron and protoporphyrin-IX may modulate the expression of Trf receptors: iron and heme induce a decrease in the number of Trf receptors; in contrast protoporphyrin-IX elicited a significant increase in the number of Trf receptors. On the basis of these data we suggest that the intracellular concentration of iron, heme and protoporphyrin-IX may represent the main factor involved in the regulation of the expression of Trf receptors.
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