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  • Title: Histamine and serotonin suppression of lymphocyte response to phytohemagglutinin and allogeneic cells.
    Author: Bonnet M, Lespinats G, Burtin C.
    Journal: Cell Immunol; 1984 Feb; 83(2):280-91. PubMed ID: 6319035.
    Abstract:
    Histamine added to murine spleen cells suppressed in vitro proliferation of lymphocytes induced by PHA or allogeneic spleen cells. Another vasoactive amine, serotonin (5-hydroxytryptamine), exerted a similar inhibitory activity on PHA- or allogeneic cell-induced lymphocyte proliferation. Anti-H2 histamine antagonists, cimetidine, metiamide, and ranitidine, blocked the histamine and serotonin suppressive effect. Cyproheptadine, an anti-H1 histamine and anti-serotonin antagonist, and methysergide, an anti-serotonin antagonist, also blocked histamine and serotonin inhibitory activities. These data suggest the presence, on lymphocytes, of receptors for serotonin which might be related to histamine receptors.
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