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  • Title: In vivo assessment of 99mTc-labeled hematoporphyrin derivative in tumor-bearing animals.
    Author: Wong DW, Mandal A, Reese IC, Brown J, Siegler R.
    Journal: Int J Nucl Med Biol; 1983; 10(4):211-8. PubMed ID: 6319312.
    Abstract:
    The efficacy of 99mTc-labeled hematoporphyrin derivative in localizing neoplasms has been investigated with tumor-bearing animal models. Spontaneous mammary adenocarcinomas of outbred CFW strain Swiss-Webster white mice and chemical carcinogen induced breast tumors in female Sprague-Dawley white rats were clearly visualized in the scintigrams. Mice tissue distribution data demonstrate favourable tumor to organ ratios sufficiently high to permit tumor detection. [99mTc]HPD appears promising as a tumor imaging agent.
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