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  • Title: Ventilation and CSF ions during isocapnic HCl and HNO3 acidosis in conscious rabbits.
    Author: Nattie EE, Reeder R.
    Journal: J Appl Physiol Respir Environ Exerc Physiol; 1983 Dec; 55(6):1758-66. PubMed ID: 6319341.
    Abstract:
    In conscious rabbits with preimplanted arterial, central venous, and cisterna magna catheters, we infused HCl or HNO3 over 9 h to reduce plasma [HCO-3] by 9-14 mmol/l. We hypothesized that greater entry into cerebrospinal fluid (CSF) of a strong anion, NO-3 vs. Cl-, would reduce the strong ion difference and the [HCO-3], and we used isocapnic conditions to minimize the effects of PCO2-specific mechanisms of CSF HCO-3 regulation. Although CSF pH decreased slightly in both groups reflecting a small increase in CSF PCO2, we observed no significant change in CSF [HCO-3]. With HCl, there was no significant increase in CSF [Cl-], even though plasma [Cl-] increased 15-16 mmol/l. With HNO3, CSF [NO-3] increased 3.6-7.9 mmol/l, owing to the 18-22 mmol/l increase in plasma [NO-3], and resulted, not in a decrease in [HCO-3], as hypothesized, but in a decrease in [Cl-]. There was no difference in the ventilatory responses of the two groups. These results emphasize the importance of PCO2-dependent mechanisms in determining the CSF [HCO-3] and indicate that the strong anion mechanisms of CSF HCO-3 regulation can utilize changes in both NO-3 and Cl-.
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