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Title: Two configurations of a channel-forming membrane protein. Author: Unwin PN, Ennis PD. Journal: Nature; ; 307(5952):609-13. PubMed ID: 6320017. Abstract: The protein oligomer forming the gap junction channel has been analysed in two Ca2+-sensitive states by electron microscopy of membranes in frozen aqueous solutions. Switching between states occurs by a small cooperative rearrangement involving tilting of the subunits, which may be responsible for the effect of Ca2+ on channel permeability in vivo.[Abstract] [Full Text] [Related] [New Search]