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  • Title: 3T3 variants unable to bind epidermal growth factor cannot complement in co-culture.
    Author: Terwilliger E, Herschman HR.
    Journal: Biochem Biophys Res Commun; 1984 Jan 13; 118(1):60-4. PubMed ID: 6320832.
    Abstract:
    A Swiss-Webster 3T3 variant, called 3T3-ENR7, unable to divide in response to epidermal growth factor was isolated by the mitogen-colchicine selection technique. Like the other EGF non-proliferative variants (3T3-NR6 and 3T3-TNR2), 3T3-ENR7 was unable to bind 125I-EGF. Pairwise co-culture of the three independently isolated EGF non-responsive variants did not restore mitogenic responsiveness to EGF.
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