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  • Title: Forskolin stimulates adenylate cyclase activity, adenosine 3',5'-monophosphate production and peptide release from the intermediate lobe of the rat pituitary gland.
    Author: Miyazaki K, Goldman ME, Kebabian JW.
    Journal: Endocrinology; 1984 Mar; 114(3):761-6. PubMed ID: 6321138.
    Abstract:
    Forskolin stimulates adenylate cyclase activity in a cell-free homogenate of the intermediate lobe (IL) of the rat pituitary gland. L-Isoproterenol, a beta-adrenergic agonist, enhances and apomorphine, a D-2 agonist, inhibits the forskolin-stimulated adenylate cyclase activity. Guanosine triphosphate is obligatory for the dopaminergic attenuation of the forskolin-enhanced enzyme activity. When tested upon enzymatically dispersed IL cells, forskolin enhances the release of both cAMP and immunoreactive alpha MSH-like peptides. These effects of forskolin upon the IL are discussed within the context of a previously published working hypothesis that cAMP in some way triggers the calcium-dependent release of hormones from the IL.
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