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  • Title: Relationship between endogenous opioids and the oestrous cycle in the rat.
    Author: Hulse GK, Coleman GJ, Copolov DL, Clements JA.
    Journal: J Endocrinol; 1984 Mar; 100(3):271-5. PubMed ID: 6321625.
    Abstract:
    The aim of this study was twofold: (1) to document changes in levels of immunoreactive beta-endorphin (Ir-beta-EP) in the hypothalamus, anterior pituitary gland, neurointermediate lobe and plasma during the oestrous cycle of the rat and (2) to investigate stress-induced changes in plasma Ir-beta-EP at different stages of the oestrous cycle. Evidence was found that Ir-beta-EP levels in the hypothalamus, anterior pituitary gland and plasma are not constant during the oestrous cycle and that the Ir-beta-EP response to stress is a function of the phase of the oestrous cycle at which stress is applied. It is suggested that fluctuations in ovarian hormones may influence oestrous Ir-beta-EP levels both under normal conditions and after exposure to stress.
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