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  • Title: Are "on-off" effects during chronic L-dopa treatment due to faulty feedback control of the nigrostriatal dopamine pathway?
    Author: Carlsson A.
    Journal: J Neural Transm Suppl; 1983; 19():153-61. PubMed ID: 6321646.
    Abstract:
    The paper reviews evidence for and against the hypothesis that the "on-off" effects observed during chronic L-dopa therapy are due to faulty feedback control of the dopaminergic nigrostriatal pathway. Such failure may be brought about by preferential desensitization of the presynaptic dopaminergic autoreceptors or by a defect in the striatonigral feedback loop. To further analyze the mechanisms underlying "on-off" effects, the development of specific dopaminergic receptor agonists, suitable for clinical investigation, might prove useful. This may be true, for example, of selective dopaminergic autoreceptor agonists, such as 3-PPP, developed by the author's research group.
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