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  • Title: Lumen-positive chloride transport potential in the early distal tubule of Triturus kidney: its absolute dependence on the presence of Na+ and K+ in the luminal fluid.
    Author: Hoshi T, Kuramochi G, Yoshitomi K.
    Journal: Jpn J Physiol; 1983; 33(5):855-61. PubMed ID: 6321832.
    Abstract:
    Microperfusion experiments with Na+-free and/or K+-free solutions revealed that the generation of Cl- -dependent lumen-positive transtubular potentials of the early distal tubule of Triturus kidney was absolutely dependent on the presence of both Na+ and K+ in the lumen. Increases in luminal Na+ or K+ concentration increased the luminal positivity in a saturable manner, and the half saturation concentration was found to be about 1 mM for both cations. The results strongly suggest that Cl- is cotransported with Na+ and K+ across the luminal membrane.
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