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  • Title: Evaluation of combination chemotherapy in Wistar/Furth rats bearing transplantable Wilms' tumor.
    Author: Green DM, Williams PD, Murphy GP.
    Journal: Oncology; 1984; 41(1):39-42. PubMed ID: 6322086.
    Abstract:
    Wistar/Furth rats received chemotherapy with vincristine, actinomycin D and adriamycin alone and in combination following renal subcapsular implantation of a transplantable murine Wilms' tumor and nephrectomy. Each agent prolonged survival significantly compared to control, and both two-drug regimens were superior to single agent therapy. The two-drug programs were equally effective. No drug regimen was effective in preventing abdominal recurrence.
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