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  • Title: The membrane glycoprotein encoded by the retroviral oncogene v-erb-B is structurally related to tyrosine-specific protein kinases.
    Author: Privalsky ML, Ralston R, Bishop JM.
    Journal: Proc Natl Acad Sci U S A; 1984 Feb; 81(3):704-7. PubMed ID: 6322166.
    Abstract:
    Avian erythroblastosis virus can transform both fibroblasts and erythroid cells to neoplastic growth. A locus within the virus genome, v-erb B, encodes a membrane glycoprotein essential for the oncogenic properties of the virus. No biochemical function has until now been attributed to the v-erb B protein. We report here that the v-erb B glycoprotein shares strong structural homologies with the tyrosine-specific protein kinases encoded by certain retroviral oncogenes. The patterns of amino acid conservation between the tyrosine-specific protein kinases and the v-erb B protein, and between the v-erb B protein and the catalytic subunit of bovine protein kinase, suggest a possible functional as well as structural relatedness.
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